Journal article
The tetrameric plant lectin BanLec neutralizes HIV through bidentate binding to specific viral glycans.
- Abstract:
-
Select lectins have powerful antiviral properties that effectively neutralize HIV-1 by targeting the dense glycan shield on the virus. Here, we reveal the mechanism by which one of the most potent lectins, BanLec, achieves its inhibition. We identify that BanLec recognises a subset of high-mannose glycans via bidentate interactions spanning the two binding sites present on each BanLec monomer that were previously considered separate carbohydrate recognition domains. We show that both sites ar...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Accepted manuscript, pdf, 609.5KB)
-
- Publisher copy:
- 10.1016/j.str.2017.03.015
Authors
Funding
+ European Research Council
More from this funder
Funding agency for:
Robinson, C
Grant:
Professorship
+ Medical Research Council
More from this funder
Funding agency for:
Robinson, C
Grant:
Professorship
MR/K024426/1
+ Royal Society
More from this funder
Funding agency for:
Benesch, J
Robinson, C
Grant:
BB/L017733/1
Professorship
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Benesch, J
Struwe, W
Grant:
BB/L017733/1
BB/L017733/1
+ National Institute of Allergy and Infectious Diseases
More from this funder
Funding agency for:
Crispin, M
Grant:
1UM1AI100663
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 25
- Issue:
- 5
- Pages:
- 773-782.e5
- Publication date:
- 2017-04-20
- Acceptance date:
- 2017-03-23
- DOI:
- ISSN:
-
1878-4186 and 0969-2126
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:691199
- UUID:
-
uuid:d1c45d29-2a51-4672-a816-2042574deb37
- Local pid:
- pubs:691199
- Source identifiers:
-
691199
- Deposit date:
- 2017-05-11
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2017
- Notes:
- © 2017 Published by Elsevier Ltd.. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: http://dx.doi.org/10.1016/j.str.2017.03.015
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record