Journal article
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
- Abstract:
-
FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellular resistance to such lesions. In vertebrates, FANCM-MHF associat...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.molcel.2010.01.039
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Authors
Bibliographic Details
- Journal:
- Molecular cell
- Volume:
- 37
- Issue:
- 6
- Pages:
- 865-878
- Publication date:
- 2010-03-01
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Source identifiers:
-
58079
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:58079
- UUID:
-
uuid:d16de287-041c-4d4f-828c-1acdab4112f9
- Local pid:
- pubs:58079
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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