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Journal article

Phase 3 efficacy analysis of a typhoid conjugate vaccine trial in Nepal

Abstract:

BACKGROUND

Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified by the World Health Organization was shown to be efficacious in a human challenge model, but data from efficacy trials in areas where typhoid is endemic are lacking.

METHODS

In this phase 3, randomized, controlled trial in Lalitpur, Nepal, in which both the participants ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1056/nejmoa1905047

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
ContEd
Role:
Author
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Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
381
Issue:
23
Pages:
2209-2218
Publication date:
2019-12-05
Acceptance date:
2019-09-23
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Pmid:
31800986
Source identifiers:
1076844
Language:
English
Keywords:
Pubs id:
pubs:1076844
UUID:
uuid:d0d7fd44-046d-42a5-9af7-dd3353c9c721
Local pid:
pubs:1076844
Deposit date:
2019-12-07

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