Journal article
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
- Abstract:
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Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 588.8KB)
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- Publisher copy:
- 10.1371/journal.pgen.1002805
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Authors
Funding
Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health
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Boston University School of Medicine
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SHARe project
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS genetics Journal website
- Volume:
- 8
- Issue:
- 7
- Article number:
- e1002805
- Publication date:
- 2012-07-01
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
- Source identifiers:
-
344337
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:344337
- UUID:
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uuid:d08d6e26-45d2-40b7-b7bd-95af0bc4dbc1
- Local pid:
- pubs:344337
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Coviello et al
- Copyright date:
- 2012
- Notes:
- This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- CC Attribution (CC BY)
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