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The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.

Abstract:

OBJECTIVE: Developing a vaccine that is cross-reactive between HCV genotypes requires data on T cell antigenic targets that extends beyond genotype-1. We characterised T cell immune responses against HCV genotype-3, the most common infecting genotype in the UK and Asia, and assessed within genotype and between genotype cross-reactivity. DESIGN: T cell targets were identified in 140 subjects with either acute, chronic or spontaneously resolved HCV genotype-3 infection using (1) overlapping pep...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publisher copy

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Publisher copy:
10.1136/gutjnl-2014-308724

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine, Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine, Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine, Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine, Biomedical Research Centre
Role:
Author
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Funding agency for:
von Delft, A
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Funding agency for:
Humphreys, IS
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Funding agency for:
Barnes, E
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Journal:
Gut
Publication date:
2015-06-19
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:ce26884d-740b-4c69-adb6-d8bff173d6c7
Source identifiers:
528593
Local pid:
pubs:528593
Language:
English
Keywords:

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