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A dynamic folded Hairpin conformation is associated with α-Globin activation in Erythroid cells

Abstract:

We investigate the three-dimensional (3D) conformations of the α-globin locus at the single-allele level in murine embryonic stem cells (ESCs) and erythroid cells, combining polymer physics models and high-resolution Capture-C data. Model predictions are validated against independent fluorescence in situ hybridization (FISH) data measuring pairwise distances, and Tri-C data identifying three-way contacts. The architecture is rearranged during the transition from ESCs to erythroid cells, assoc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2020.01.044

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Division:
MSD
Department:
RDM
Role:
Author
ORCID:
0000-0002-4016-6158
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Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Cell Reports Journal website
Volume:
30
Issue:
7
Pages:
2125-2135.e5
Publication date:
2020-02-18
Acceptance date:
2020-01-14
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
32075757
Language:
English
Keywords:
Pubs id:
1089195
Local pid:
pubs:1089195
Deposit date:
2020-03-09

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