Journal article
Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape
- Abstract:
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Recent studies have suggested greater HIV cure potential among infected children than adults. A major obstacle to HIV eradication in adults is that the viral reservoir is largely comprised of HIV-specific cytotoxic T lymphocyte (CTL) escape variants. We here evaluate the potential for CTL in HIV-infected slow-progressor children to play an effective role in "shock-and-kill" cure strategies. Two distinct subgroups of children were identified on the basis of viral load. Unexpectedly, in both gr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.5MB)
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- Publisher copy:
- 10.1084/jem.20162123
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Authors
Funding
+ Mochida Memorial Foundation for Medical and Pharmaceutical Research
More from this funder
Funding agency for:
Mori, M
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Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Experimental Medicine Journal website
- Volume:
- 214
- Issue:
- 11
- Pages:
- 3239-3261
- Publication date:
- 2017-10-05
- Acceptance date:
- 2017-08-30
- DOI:
- EISSN:
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1540-9538
- ISSN:
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0022-1007
- Pmid:
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28983013
- Source identifiers:
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734799
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:734799
- UUID:
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uuid:cd187c35-58fb-429b-82c4-8e6471bacfb3
- Local pid:
- pubs:734799
- Deposit date:
- 2017-10-12
Terms of use
- Copyright holder:
- © 2017 Leitman et al
- Copyright date:
- 2017
- Notes:
-
This article is distributed under the terms of an Attribution–Noncommercial–Share
Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org
/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–
Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
- Licence:
- Other
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