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Journal article

Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape

Abstract:

Recent studies have suggested greater HIV cure potential among infected children than adults. A major obstacle to HIV eradication in adults is that the viral reservoir is largely comprised of HIV-specific cytotoxic T lymphocyte (CTL) escape variants. We here evaluate the potential for CTL in HIV-infected slow-progressor children to play an effective role in "shock-and-kill" cure strategies. Two distinct subgroups of children were identified on the basis of viral load. Unexpectedly, in both gr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20162123

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
SSD
Department:
Divisional Administration
Sub department:
Oxford Martin School
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Funding agency for:
Leitman, E
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Funding agency for:
Gall, A
Grant:
WT 104748MA
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Funding agency for:
Goulder, P
Grant:
098051
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Funding agency for:
Prendergast, A
Grant:
093768/Z/15/X
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
214
Issue:
11
Pages:
3239-3261
Publication date:
2017-10-05
Acceptance date:
2017-08-30
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Pmid:
28983013
Source identifiers:
734799
Language:
English
Keywords:
Pubs id:
pubs:734799
UUID:
uuid:cd187c35-58fb-429b-82c4-8e6471bacfb3
Local pid:
pubs:734799
Deposit date:
2017-10-12

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