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CXCR3+ T follicular helper cells induced by co-administration of RTS,S/AS01B and viral vectored vaccines are associated with reduced immunogenicity and efficacy against Malaria

Abstract:

Malaria remains a significant cause of morbidity and mortality in sub-Saharan Africa. An efficacious vaccine will be an essential part of attempts to eradicate the disease. A vaccine strategy targeting multiple stages lifecycle stages may be required to achieve a high level of efficacy. In a series of phase IIa clinical trials we tested different regimens of two vaccine platforms: RTS,S/AS01B, which induces antibody responses to target sporozoites and viral-vectored vaccines ChAd63-MVA ME-TRA...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2018.01660

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
ORCID:
0000-0001-9827-9836
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Jenner Institute
Oxford college:
St Cross College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Jenner Institute
Oxford college:
St Hugh's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Jenner Institute
Oxford college:
Kellogg College
Role:
Author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
1660
Publication date:
2018-07-30
Acceptance date:
2018-07-04
DOI:
EISSN:
1664-3224
Keywords:
Pubs id:
pubs:864370
UUID:
uuid:cb51ac05-d30d-4030-9be4-044bc81a87ea
Local pid:
pubs:864370
Deposit date:
2018-07-04

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