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Genetic predisposition to coronary artery disease in type 2 diabetes

Abstract:

Background - Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes (T2D). Methods - To test whether this reflects differential genetic influences on CAD-risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66,643 subjects (27,708 with CAD and 24,259 with T2D). Variants showing apparent association with CAD in stratified analyses and/or evidence of interaction were evaluated in a further 117,787 subjects (16,694 with...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/circgen.119.002769

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Role:
Author
ORCID:
0000-0002-9809-1398
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Role:
Author
ORCID:
0000-0002-7501-6598
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Role:
Author
ORCID:
0000-0002-6205-9994
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Role:
Author
ORCID:
0000-0001-8506-3585
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Role:
Author
ORCID:
0000-0003-1515-2421
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
Circulation: Genomic and Precision Medicine Journal website
Volume:
13
Issue:
6
Article number:
e002769
Publication date:
2020-08-13
Acceptance date:
2020-05-15
DOI:
EISSN:
2574-8300
ISSN:
2574-8300
Language:
English
Keywords:
Pubs id:
1126290
Local pid:
pubs:1126290
Deposit date:
2020-11-09

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