Thesis
Epigenetic approaches to the study of macrophages in atherosclerosis
- Abstract:
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Coronary artery disease (CAD) is caused by atherosclerosis, a chronic inflammatory response to modified lipoproteins. A key pathophysiological event is the lipid-induced transformation of macrophages into lipid-laden foam cells and their accumulation in atherosclerotic plaques. Heritable CAD risk is associated with common genetic variants at over 40 genomic loci; the underlying causal mechanisms remain largely unknown and could affect transcriptional regulation in foam cells. Epigenetic and g...
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Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:cb314b79-afc5-48a0-aa05-fe57843b8dcc
- Local pid:
- ora:12547
- Deposit date:
- 2016-07-15
Terms of use
- Copyright holder:
- Reschen, M
- Copyright date:
- 2015
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