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Thesis

Epigenetic approaches to the study of macrophages in atherosclerosis

Abstract:

Coronary artery disease (CAD) is caused by atherosclerosis, a chronic inflammatory response to modified lipoproteins. A key pathophysiological event is the lipid-induced transformation of macrophages into lipid-laden foam cells and their accumulation in atherosclerotic plaques. Heritable CAD risk is associated with common genetic variants at over 40 genomic loci; the underlying causal mechanisms remain largely unknown and could affect transcriptional regulation in foam cells. Epigenetic and g...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
St Cross College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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