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Thesis

Characterisation of chromatin modifiers in endometrial cancer

Abstract:

Chromatin organization is a critical regulator of gene expression and cell phenotype, and is frequently dysregulated in cancer. Endometrial cancer (EC) is the most common gynecological malignancy, and casues significant morbidity and mortality. EC is notable for recurrent alterations in chromatin including the ARID1A gene – a key component of the SWI/SNF remodeling complex – has emerged as a prevalent driver in EC, along with other remodelers such as CHD4 and BCOR

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Institution:
University of Oxford
Division:
MSD
Role:
Author

Contributors

Institution:
University of Oxford
Role:
Supervisor
ORCID:
0000-0002-4617-962X
Institution:
University of Oxford
Role:
Supervisor
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Name:
Wellcome Trust
Funder identifier:
https://ror.org/029chgv08
Funding agency for:
Kedzierska, KZ
Grant:
220048/Z/19/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:
Language:
English
Keywords:
Subjects:
Deposit date:
2024-06-26

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