Journal article
Hemolytic C-type lectin CEL-III from sea cucumber expressed in transgenic mosquitoes impairs malaria parasite development.
- Abstract:
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The midgut environment of anopheline mosquitoes plays an important role in the development of the malaria parasite. Using genetic manipulation of anopheline mosquitoes to change the environment in the mosquito midgut may inhibit development of the malaria parasite, thus blocking malaria transmission. Here we generate transgenic Anopheles stephensi mosquitoes that express the C-type lectin CEL-III from the sea cucumber, Cucumaria echinata, in a midgut-specific manner. CEL-III has strong and ra...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Version of record, pdf, 393.3KB)
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- Publisher copy:
- 10.1371/journal.ppat.0030192
Authors
Funding
Ministry of Sports of Japan
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Ministry of Education of Japan
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Ministry of Culture of Japan
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS pathogens Journal website
- Volume:
- 3
- Issue:
- 12
- Pages:
- e192
- Publication date:
- 2007-12-01
- DOI:
- EISSN:
-
1553-7374
- ISSN:
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1553-7366
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:c8c23089-6bfb-4015-816c-b0066eedb745
- Local pid:
- pubs:257938
- Source identifiers:
-
257938
- Deposit date:
- 2013-02-20
Terms of use
- Copyright holder:
- Yoshida et al
- Copyright date:
- 2007
- Notes:
- © 2007 Yoshida et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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