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Journal article

Identification of novel serodiagnostic signatures of typhoid fever using a salmonella proteome array

Abstract:

Current diagnostic tests for typhoid fever, the disease caused by Salmonella Typhi, are poor. We aimed to identify serodiagnostic signatures of typhoid fever by assessing microarray signals to 4,445 S. Typhi antigens in sera from 41 participants challenged with oral S. Typhi. We found broad, heterogeneous antibody responses with increasing IgM/IgA signals at diagnosis. In down-selected 250-antigen arrays we validated responses in a second challenge cohort (n = 30), and selected diagnostic sig...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fmicb.2017.01794

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Grant:
Marie Curie Research Fellow
Oxford Martin School More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Microbiology Journal website
Volume:
8
Pages:
1794
Publication date:
2017-09-01
Acceptance date:
2017-09-05
DOI:
ISSN:
1664-302X
Source identifiers:
731395
Keywords:
Pubs id:
pubs:731395
UUID:
uuid:c707a9b4-d499-4a0a-9f48-3ac8eeb9e204
Local pid:
pubs:731395
Deposit date:
2017-10-01

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