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Thesis

Investigation of type 2 cytokine pathways as modulators of haematopoiesis during chronic inflammation

Abstract:

Chronic inflammatory diseases often promote bone marrow (BM) myelopoiesis at the expense of erythropoiesis and lymphopoiesis, facilitating production of mature myeloid cells to sustain the inflammatory response. In previous studies, type 2 cytokines, including IL-4, IL-5, and IL-33, have been suggested as possible regulators of haematopoiesis, but their role in modulation of haematopoiesis during inflammation was unknown. Spondyloarthritis (SpA) is a chronic inflammatory disease of peopl...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0001-7988-9997

Contributors

Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
St Edmund Hall
Role:
Supervisor
ORCID:
0000-0001-5739-7625
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
St Edmund Hall
Role:
Supervisor
Versus Arthritis More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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