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Mechanistic Studies of JMJD6, Fe(II) and 2OG dependent lysyl hydroxylase

Abstract:

JMJD6 or PSR (phosphatidyl serine receptor) was initially proposed to be a membrane receptor involved in apoptotic cell clearance by recognition of apoptotic cells. However, sequence analyses implied the presence of a jelly roll or double stranded beta helix (DSBH) structural domain in PSR/JMJD6 and similarity with JmjC family of enzymes which are involved in chromatin regulation. Subsequently, PSR was renamed as JMJD6 and was reported to be a histone arginine demethylase. Previous work fr...

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Institution:
University of Oxford
Research group:
Schofield Group
Oxford college:
Wolfson College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:c45f420d-ec90-4b1c-83ee-2071c6288161
Local pid:
ora:9604

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