Thesis
Molecular studies of stiff skin-causing mutations in fibrillin-1
- Abstract:
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Fibrillin-1 is the main component of the 10-12 nm microfibrils, which are found in several elastic and non-elastic tissues. Human fibrillin-1 contains multiple calcium-binding epidermal growth factor-like (cbEGF) domains interspersed with transforming growth factor β-binding protein-like (TB) domains. TB4 domain contains a flexible RGD loop which mediates cell adhesion via αVβ3, α5β1 and αVβ6 integrins. Mutations which introduce amino acid substitutions into TB4 are associated with a wide ...
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Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:c23ac97b-dbf3-44b3-9e56-7a860038519e
- Local pid:
- ora:7681
- Deposit date:
- 2013-12-13
Terms of use
- Copyright holder:
- Iqbal, S
- Copyright date:
- 2011
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