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The putative lithium-mimetic ebselen reduces impulsivity in rodent models

Abstract:

Background: Deficits in impulse control feature in many psychiatric conditions including bipolar disorder, suicidality and addictions. Lithium lowers impulsivity in clinical populations and decreases pathological gambling in experimental medicine studies, but suffers from adverse effects, poor compliance and a low therapeutic index. Aims: Recently we identified that the neuroprotective agent ebselen, which is reportedly safe in humans, inhibited inositol monophosphatase (IMPase), a candidat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/0269881118784876

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Biomedical Services
Role:
Author
ORCID:
0000-0001-9774-3692
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Role:
Author
ORCID:
0000-0002-1140-2422
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Psychiatry
Role:
Author
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Publisher:
Sage Publications Ltd. Publisher's website
Journal:
Journal of Psychopharmacology Journal website
Publication date:
2018-07-10
Acceptance date:
2018-06-03
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
Pmid:
29986609
Source identifiers:
867538
Language:
English
Keywords:
Pubs id:
pubs:867538
UUID:
uuid:c013359d-5b2d-4784-8b44-3d2d13984ddb
Local pid:
pubs:867538
Deposit date:
2018-08-17

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