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Journal article

Frequent homologous recombination deficiency in high-grade endometrial carcinomas

Abstract:

Purpose The elevated levels of somatic copy number alterations (SCNA) in a subset of high-risk endometrial cancers (EC) are suggestive of defects in pathways governing genome integrity. We sought to assess the prevalence of homologous recombination deficiency (HRD) in EC and its association with histopathological and molecular characteristics.

Experimental Design Fresh tumor tissue was prospectively collected from 36 EC, and functional HRD was exami...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1078-0432.ccr-18-1443

Authors


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Role:
Author
ORCID:
0000-0002-6578-7225
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Funding agency for:
Glaire, M
Grant:
Clinical Training Fellowship
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Funding agency for:
Church, D
Grant:
Clinician Scientist Fellowship: AMS-CSF4-Church
National Institute for Health Research More from this funder
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
25
Issue:
3
Pages:
1087-1097
Publication date:
2018-11-09
Acceptance date:
2018-11-06
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Pmid:
30413523
Source identifiers:
943704
Language:
English
Pubs id:
pubs:943704
UUID:
uuid:be8f7d8f-f9ef-433d-a083-e7a14a5483f1
Local pid:
pubs:943704
Deposit date:
2018-11-19

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