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Thesis

Needle-free vaccination: formulation and dermal delivery of diphtheria toxin CRM197 mutant

Abstract:

The unsafe use of needles propagates cross infections with bloodborne pathogens and reduces the positive impact of vaccinations on global health. While a plethora of needle-free injection devices exist, the reformulation of protein-based vaccines is largely empirical and costly, which presents a barrier to their widespread clinical application.

This thesis contributes to the identification of approaches that facilitate rapid vaccine reformulation and enhance the immunogenicity of ne...

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Research group:
Oxford Vaccine Group (OVG), Biomedical Ultrasonics, Biotherapy and Biopharmaceuticals Laboratory (BUBBL)
Oxford college:
St Cross College
Role:
Author
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Division:
MSD
Department:
Paediatrics
Role:
Author

Contributors

Division:
MSD
Department:
Paediatrics
Role:
Supervisor
Division:
MSD
Department:
Paediatrics
Role:
Supervisor
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Funding agency for:
Weissmueller, N
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:be74f39b-1f36-451c-8200-4f14b701bcee
Local pid:
ora:8083
Deposit date:
2014-02-25

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