Needle-free vaccination: formulation and dermal delivery of diphtheria toxin CRM197 mutant
The unsafe use of needles propagates cross infections with bloodborne pathogens and reduces the positive impact of vaccinations on global health. While a plethora of needle-free injection devices exist, the reformulation of protein-based vaccines is largely empirical and costly, which presents a barrier to their widespread clinical application.
This thesis contributes to the identification of approaches that facilitate rapid vaccine reformulation and enhance the immunogenicity of ne...Expand abstract
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- Oxford University, UK
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- Nikolas Weissmueller
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