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HIV-infected sex workers with beneficial HLA-variants are potential hubs for selection of HIV-1 recombinants that may affect disease progression

Abstract:

Cytotoxic T lymphocyte (CTL) responses against the HIV Gag protein are associated with lowering viremia; however, immune control is undermined by viral escape mutations. The rapid viral mutation rate is a key factor, but recombination may also contribute. We hypothesized that CTL responses drive the outgrowth of unique intra-patient HIV-recombinants (URFs) and examined gag sequences from a Kenyan sex worker cohort. We determined whether patients with HLA variants associated with effective CTL...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep11253

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Role:
Author
ORCID:
0000-0002-1081-6594
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Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
5
Issue:
1
Pages:
11253
Publication date:
2015-06-17
Acceptance date:
2015-05-11
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
26082240
Source identifiers:
527693

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