Thesis
Molecular dynamics simulation studies of transmembrane signalling proteins
- Abstract:
-
Receptor tyrosine kinases (RTKs) are a major class of cell surface receptors, important in cell signalling events associated with a variety of functions. High-throughput (HTP), coarse-grained molecular dynamics (CG-MD) simulations have been used to investigate the dimerization of the transmembrane (TM) domain of selected RTKs, including epidermal growth factor receptor (EGFR) and muscle-specific kinase (MuSK). EGFR activation requires not only a specific TM dimer interface, but also a prop...
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Funding
+ Yayasan Khazanah-OCIS Oxford Merdeka Scholarship
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Funding agency for:
Halim, K
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:bc9e1e0e-433c-4adb-8374-1065eac0f37e
- Local pid:
- ora:12248
- Deposit date:
- 2015-09-17
Terms of use
- Copyright holder:
- Halim, K
- Copyright date:
- 2014
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