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Thesis

Novel signalling pathways regulating epithelial-mesenchymal transition in bone metastatic prostate cancer

Abstract:

Prostate cancer (PCa) cells predominantly metastasize to bone and the complex crosstalk between PCa cells and osteoblasts (bone-forming cells) and osteoclasts (bone-destroying cells) leads to increased tumour growth and worsening of bone disease. Understanding the mechanisms of PCa bone metastasis can identify the aggressive fraction of PCa resulting in earlier intervention. The ability of PCa cells to express bone cell-specific features, termed osteomimicry, could potentially explain the ...

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Research group:
Bone Oncology (Dr. Claire Edwards)
Oxford college:
St Edmund Hall
Role:
Author

Contributors

Division:
MSD
Department:
Surgical Sciences
Role:
Supervisor
Division:
MSD
Department:
Surgical Sciences
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:bc90d3e0-420c-424f-b6ea-5567cbb21529
Local pid:
ora:11804
Deposit date:
2015-07-07

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