Thesis
Novel signalling pathways regulating epithelial-mesenchymal transition in bone metastatic prostate cancer
- Abstract:
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Prostate cancer (PCa) cells predominantly metastasize to bone and the complex crosstalk between PCa cells and osteoblasts (bone-forming cells) and osteoclasts (bone-destroying cells) leads to increased tumour growth and worsening of bone disease. Understanding the mechanisms of PCa bone metastasis can identify the aggressive fraction of PCa resulting in earlier intervention. The ability of PCa cells to express bone cell-specific features, termed osteomimicry, could potentially explain the ...
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Authors
Contributors
+ Edwards, CM
Division:
MSD
Department:
Surgical Sciences
Role:
Supervisor
+ Hamdy, FC
Division:
MSD
Department:
Surgical Sciences
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:bc90d3e0-420c-424f-b6ea-5567cbb21529
- Local pid:
- ora:11804
- Deposit date:
- 2015-07-07
Terms of use
- Copyright holder:
- Rao, SR
- Copyright date:
- 2014
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