Thesis
Bioprocessing of oncolytic group B adenovirus for scalable production
- Abstract:
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The central aim of this thesis was to develop strategies to improve the manufacture of the group B chimeric oncolytic adenovirus, ColoAd1, which rapidly kills and lyses host cells. In attempting to improve the cellular yield of ColoAd1, this thesis therefore sought to identify host infection-related factors that limited ColoAd1 production.
In the widely-used manufacturing cell line, HEK293, ColoAd1 replication depleted intracellular ATP earlier than Ad11p and activated the intracell...
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Authors
Contributors
+ Seymour, L
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
+ Fisher, K
Department:
PsiOxus Therapeutics
Role:
Supervisor
Funding
Biotechnology and Biological Sciences Research Council
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PsiOxus Therapeutics
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:bc62bd13-f43f-4d35-8975-7fc341ce209c
- Deposit date:
- 2015-10-30
Related Items
Terms of use
- Copyright holder:
- Cooper, L
- Copyright date:
- 2014
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