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Thesis

Bioprocessing of oncolytic group B adenovirus for scalable production

Abstract:

The central aim of this thesis was to develop strategies to improve the manufacture of the group B chimeric oncolytic adenovirus, ColoAd1, which rapidly kills and lyses host cells. In attempting to improve the cellular yield of ColoAd1, this thesis therefore sought to identify host infection-related factors that limited ColoAd1 production.

In the widely-used manufacturing cell line, HEK293, ColoAd1 replication depleted intracellular ATP earlier than Ad11p and activated the intracell...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
Department:
PsiOxus Therapeutics
Role:
Supervisor
Biotechnology and Biological Sciences Research Council More from this funder
PsiOxus Therapeutics More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:bc62bd13-f43f-4d35-8975-7fc341ce209c
Deposit date:
2015-10-30

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