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Dexamethasone in hospitalized patients with Covid-19 — preliminary report

Abstract:

BACKGROUND

Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death.

METHODS

In this controlled, open-label trial comparing a range of possible treatments in patients who were hospitalized with Covid-19, we randomly assigned patients to receive oral or intravenous dexamethasone (at a dose of...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1056/NEJMoa2021436

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Subgroup:
NPEU
Role:
Author
ORCID:
0000-0001-9571-0715
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Contributors

Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
384
Issue:
8
Pages:
693-704
Publication date:
2020-07-17
Acceptance date:
2020-07-14
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Pubs id:
1118880
Local pid:
pubs:1118880
Language:
English
Keywords:

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