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Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin

Abstract:

Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian genome function; however, many of its physical features at the single-cell level remain underexplored. Here, we use live- and fixed-cell 3D super-resolution and scanning electron microscopy to analyze structural and functional nuclear organization in somatic cells. We identify chains of interlinked ~200- to 300-nm-wide chromatin domains (CDs) composed of aggregated nucleosomes that can overlap with individu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/566638

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
6
Issue:
39
Article number:
eaba8811
Publication date:
2020-09-23
Acceptance date:
2020-07-13
DOI:
EISSN:
2375-2548
Language:
English
Keywords:
Pubs id:
1075971
Local pid:
pubs:1075971
Deposit date:
2020-06-25

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