Thesis
In silico molecular understanding of opioid receptor activation
- Abstract:
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This thesis explores the behaviour the homo sapiens δ opioid receptor (δ OR) in complex with a variety of morphinan (morphine derivatives) opioids, aiming to answer whether molecular dynamics (MD) tools can be used to determine the molecular underpinning of opioid structure-activity relationship.
To do so, the results of conventional MD simulations are reported and analysed to shed light on the local changes to the binding pocket, and a novel method, N-Body Information Theo...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Keywords:
- Subjects:
- UUID:
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uuid:ba2a4133-aecf-471f-b9ee-d251475005cd
- Deposit date:
- 2019-06-04
Related Items
Terms of use
- Copyright holder:
- Velgy, N
- Copyright date:
- 2018
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