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Genetic susceptibility to tuberculosis in Africans: a genome-wide scan.

Abstract:

Human genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to search for regions of the human genome containing tuberculosis-susceptibility genes. This approach uses sibpair families that contain two full siblings who have both been affected by clinical tuberculosis. For any chromosomal region containing a major tuberculosis-susceptibility gene, affected sibpairs inherit the same pare...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.140201897

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
14
Pages:
8005-8009
Publication date:
2000-07-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
31700

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