Journal article
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
- Abstract:
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Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG: studies using single variants and those using multiple variants...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 891.4KB)
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- Publisher copy:
- 10.1038/s41467-018-03109-y
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Issue:
- 1
- Pages:
- 711
- Publication date:
- 2018-02-01
- Acceptance date:
- 2018-01-19
- DOI:
- EISSN:
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2041-1723
- Pmid:
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29459775
- Source identifiers:
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825654
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:825654
- UUID:
-
uuid:b85a7a30-7b37-4106-a0e9-f52d769a0a64
- Local pid:
- pubs:825654
- Deposit date:
- 2018-03-02
Terms of use
- Copyright holder:
- McCarthy et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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