Journal article
Site-selective chemical protein glycosylation protects from autolysis and proteolytic degradation.
- Abstract:
-
Glycosylation is often cited as having a stabilizing effect upon proteins with respect to proteolysis, thermolysis and other forms of degradation. We present here a model study on an autolytic protease that has been chemically glycosylated to produce single glycoforms. The resulting glycosylated enzymes are more stable with respect to their own autolytic degradation and that by other proteases. Kinetic parameters for protease activity with respect to the degradation of small-molecule amide su...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.carres.2009.06.033
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Authors
Bibliographic Details
- Journal:
- Carbohydrate research
- Volume:
- 344
- Issue:
- 12
- Pages:
- 1508-1514
- Publication date:
- 2009-08-01
- DOI:
- EISSN:
-
1873-426X
- ISSN:
-
0008-6215
- Source identifiers:
-
34800
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:34800
- UUID:
-
uuid:b45f09b1-b852-42c5-95cb-190bbf7f2c85
- Local pid:
- pubs:34800
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2009
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