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Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria

Abstract:

Transcription in bacteria is controlled by multiple molecular mechanisms that precisely regulate gene expression. It has been recently shown that initial RNA synthesis by the bacterial RNA polymerase (RNAP) is interrupted by pauses; however, the pausing determinants and the relationship of pausing with productive and abortive RNA synthesis remain poorly understood. Using single-molecule FRET and biochemical analysis, here we show that the pause encountered by RNAP after the synthesis of a 6-n...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-03902-9

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Role:
Author
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EPA Cephalosporin Junior Research Fellowship, Linacre College, Oxford More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article number 1478
Publication date:
2018-04-16
Acceptance date:
2018-03-20
DOI:
ISSN:
2041-1723
Source identifiers:
892200
Pubs id:
pubs:892200
UUID:
uuid:b3625aa0-3b51-4a57-932d-205142c5c192
Local pid:
pubs:892200
Deposit date:
2018-08-02

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