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A pro-survival DNA damage-induced cytoplasmic interferon response is mediated by end-resection factors, and is limited by Trex1

Abstract:

Radiotherapy and chemotherapy are effective treatment methods for many types of cancer, but resistance is common. Recent findings indicate that anti-viral type I interferon (IFN) signaling is induced by these treatments. However, the underlying mechanisms still need to be elucidated. Expression of a set of interferon-stimulated genes comprises an IFN-related DNA damage resistance signature (IRDS), which correlates strongly with resistance to radiotherapy and chemotherapy across different tumo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
University College
Role:
Author
British Columbia Cancer Agency Branch More from this funder
Cancer Research UK More from this funder
More from this funder
Grant:
core funding of the MRC Human Immunology Unit
Breast Cancer Research Foundation More from this funder
Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genes and Development Journal website
Volume:
31
Issue:
4
Pages:
353-369
Publication date:
2017-03-09
Acceptance date:
2017-02-09
EISSN:
1549-5477
ISSN:
0890-9369
Source identifiers:
680473
Pubs id:
pubs:680473
UUID:
uuid:af97638a-d3c3-484e-97f1-96769ff51581
Local pid:
pubs:680473
Deposit date:
2017-02-16

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