Journal article
A pro-survival DNA damage-induced cytoplasmic interferon response is mediated by end-resection factors, and is limited by Trex1
- Abstract:
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Radiotherapy and chemotherapy are effective treatment methods for many types of cancer, but resistance is common. Recent findings indicate that anti-viral type I interferon (IFN) signaling is induced by these treatments. However, the underlying mechanisms still need to be elucidated. Expression of a set of interferon-stimulated genes comprises an IFN-related DNA damage resistance signature (IRDS), which correlates strongly with resistance to radiotherapy and chemotherapy across different tumo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
British Columbia Cancer Agency Branch
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Cancer Research UK
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+ Medical Research Council
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Grant:
core funding of the MRC Human Immunology Unit
Breast Cancer Research Foundation
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Bibliographic Details
- Publisher:
- Cold Spring Harbor Laboratory Press Publisher's website
- Journal:
- Genes and Development Journal website
- Volume:
- 31
- Issue:
- 4
- Pages:
- 353-369
- Publication date:
- 2017-03-09
- Acceptance date:
- 2017-02-09
- EISSN:
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1549-5477
- ISSN:
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0890-9369
- Source identifiers:
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680473
Item Description
- Pubs id:
-
pubs:680473
- UUID:
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uuid:af97638a-d3c3-484e-97f1-96769ff51581
- Local pid:
- pubs:680473
- Deposit date:
- 2017-02-16
Terms of use
- Copyright holder:
- Erdal et al
- Copyright date:
- 2017
- Notes:
- © 2017 Erdal et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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