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Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases

Abstract:

Multi-subunit Cullin-RING E3 ligases often use repeat domain proteins as substrate-specific adaptors. Structures of these macromolecular assemblies are determined for the F-box-containing leucine-rich repeat and WD40 repeat families, but not for the suppressor of cytokine signaling (SOCS)-box-containing ankyrin repeat proteins (ASB1-18), which assemble with Elongins B and C and Cul5. We determined the crystal structures of the ternary complex of ASB9-Elongin B/C as well as the interacting N-t...

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Publisher copy:
10.1016/j.jmb.2013.06.015

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
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Journal:
Journal of Molecular Biology
Volume:
425
Issue:
17
Pages:
3166-3177
Publication date:
2013-09-09
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Source identifiers:
419300
Language:
English
Keywords:
Pubs id:
pubs:419300
UUID:
uuid:ae2b6783-c4b9-4240-95e1-1955b325f1cd
Local pid:
pubs:419300
Deposit date:
2013-11-17

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