Journal article
Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis.
- Abstract:
-
Systemic amyloidosis is a fatal disorder caused by pathological extracellular deposits of amyloid fibrils that are always coated with the normal plasma protein, serum amyloid P component (SAP). The small-molecule drug, miridesap, [(R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC)] depletes circulating SAP but leaves some SAP in amyloid deposits. This residual SAP is a specific target for dezamizumab, a fully humanized monoclonal IgG1 anti-SAP antibo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1126/scitranslmed.aan3128
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Authors
Funding
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Translational Medicine Journal website
- Volume:
- 10
- Issue:
- 422
- Article number:
- eaan3128
- Publication date:
- 2018-01-03
- Acceptance date:
- 2017-09-26
- DOI:
- EISSN:
-
1946-6242
- ISSN:
-
1946-6234
- Pmid:
-
29298867
- Source identifiers:
-
1033401
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1033401
- UUID:
-
uuid:adf41c20-48b6-4020-b8bc-f0de6f3ec82a
- Local pid:
- pubs:1033401
- Deposit date:
- 2019-07-18
Terms of use
- Copyright holder:
- Richards et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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