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Delaminated layered double hydroxide delivers DNA molecules as sandwich nanostructure into cells via a non-endocytic pathway

Abstract:

Layered double hydroxides (LDHs) are effective molecular carriers in cytological research, gene therapy, and transgenic applications. Herein, we investigated the internalization behavior of the LDH-DNA bioconjugates via a microscopic approach and analyzed the internalization pathway by dissipative particle dynamics (DPD) simulations. We experimentally found that LDH can efficiently carry DNA into the nucleus of cell in BY-2 suspension cells. Furthermore, atomic force microscopy and X-ray diff...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.scib.2017.04.004

Authors


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Fundamental Research Funds for the Central Universities More from this funder
National Natural Science Foundation of China More from this funder
NSFC-Guangdong Joint Fund More from this funder
Beijing Nova Programme More from this funder
Beijing University of Chemical Technology More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Science Bulletin Journal website
Volume:
62
Issue:
10
Pages:
686-692
Publication date:
2017-04-13
Acceptance date:
2017-04-01
DOI:
EISSN:
2095-9281
ISSN:
2095-9273
Source identifiers:
701172
Keywords:
Pubs id:
pubs:701172
UUID:
uuid:ad5fbc42-bf9a-4467-bf3b-a66e505cb0c1
Local pid:
pubs:701172
Deposit date:
2017-12-13

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