Journal article
Delaminated layered double hydroxide delivers DNA molecules as sandwich nanostructure into cells via a non-endocytic pathway
- Abstract:
-
Layered double hydroxides (LDHs) are effective molecular carriers in cytological research, gene therapy, and transgenic applications. Herein, we investigated the internalization behavior of the LDH-DNA bioconjugates via a microscopic approach and analyzed the internalization pathway by dissipative particle dynamics (DPD) simulations. We experimentally found that LDH can efficiently carry DNA into the nucleus of cell in BY-2 suspension cells. Furthermore, atomic force microscopy and X-ray diff...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Accepted manuscript, pdf, 1.9MB)
-
- Publisher copy:
- 10.1016/j.scib.2017.04.004
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Fundamental Research Funds for the Central Universities
More from this funder
National Natural Science Foundation of China
More from this funder
NSFC-Guangdong Joint Fund
More from this funder
Beijing Nova Programme
More from this funder
Beijing University of Chemical Technology
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Science Bulletin Journal website
- Volume:
- 62
- Issue:
- 10
- Pages:
- 686-692
- Publication date:
- 2017-04-13
- Acceptance date:
- 2017-04-01
- DOI:
- EISSN:
-
2095-9281
- ISSN:
-
2095-9273
- Source identifiers:
-
701172
Item Description
- Keywords:
- Pubs id:
-
pubs:701172
- UUID:
-
uuid:ad5fbc42-bf9a-4467-bf3b-a66e505cb0c1
- Local pid:
- pubs:701172
- Deposit date:
- 2017-12-13
Terms of use
- Copyright holder:
- Science China Press
- Copyright date:
- 2017
- Notes:
- © 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: http://dx.doi.org/10.1016/j.scib.2017.04.004
If you are the owner of this record, you can report an update to it here: Report update to this record