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Thesis

Polymer carriers of toll-like receptor-7/8 agonists as vaccine adjuvants

Abstract:

There is currently a need for vaccine adjuvants that are effective for eliciting Th1-type CD4 and CD8 T cell responses when formulated with protein and peptide-based subunit vaccines. Some of the most promising adjuvants in this regard are combined small molecule Toll-like receptor-7/8 agonists (TLR-7/8a). However, poor pharmacokinetic properties have precluded TLR-7/8a for use in vaccines.

In this thesis, polymer carriers were used to control pharmacokinetics and to modulate activi...

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Institution:
University of Oxford
Division:
MSD
Research group:
Department of Oncology, Len Seymour Group
Oxford college:
St John's College
Role:
Author

Contributors

Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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