Thesis
The role of nucleoprotein in transcription and replication of the Influenza virus genome
- Abstract:
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The eight vRNA genome segments of influenza A virus are bound by the viral RNA polymerase at the 5' and 3' ends, and associated with oligomeric nucleoprotein (NP) to form viral ribonucleoprotein (vRNP) complexes. These vRNP complexes carry out both viral transcription and replication within the nucleus of the host cell. The role of NP in viral transcription and replication, although essential, is not well understood. The findings presented in this thesis support a role for NP in the ...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Awarding institution:
- University of Oxford
Terms of use
- Copyright date:
- 2015
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