Journal article
A new mechanism for β-lactamases: Class D enzymes degrade 1β-methyl carbapenems through lactone formation
- Abstract:
-
β-Lactamases threaten the clinical use of carbapenems, which are considered antibiotics of last resort. The classical mechanism of serine carbapenemase catalysis proceeds through hydrolysis of an acyl-enzyme intermediate. We show that class D β-lactamases also degrade clinically used 1β-methyl-substituted carbapenems through the unprecedented formation of a carbapenem-derived β-lactone. β-Lactone formation results from nucleophilic attack of the carbapenem hydroxyethyl side chain on the ester...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.3MB)
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- Publisher copy:
- 10.1002/anie.201711308
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Authors
Funding
IMI ENABLE
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GSK Tres Contos
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie International Edition Journal website
- Volume:
- 57
- Issue:
- 5
- Pages:
- 1282-1285
- Publication date:
- 2018-01-05
- Acceptance date:
- 2017-12-13
- DOI:
- EISSN:
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1521-3773
- ISSN:
-
1433-7851
- Pmid:
-
29236332
- Source identifiers:
-
811183
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:811183
- UUID:
-
uuid:abc26748-d457-482c-8535-6c2670b04fea
- Local pid:
- pubs:811183
- Deposit date:
- 2018-04-12
Terms of use
- Copyright holder:
- © 2018 Lohans Published by Wiley-VCH Verlag GmbH and Co KGaA
- Copyright date:
- 2018
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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