Journal article icon

Journal article

Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

Abstract:

Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP participants and n = 86 healthy controls) and facial EMG (n = 3 CIP participants and n = 8 healthy controls) we have found that these patients also have abnormalities in the encoding of affective touch which is mediated by the specialised afferents; C-low th...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1093/brain/awab482

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Harris Manchester College
Role:
Author
ORCID:
0000-0002-0708-7335
More by this author
Role:
Author
ORCID:
0000-0002-5972-0913
Expand authors...
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Place of publication:
England
Publication date:
2021-12-27
Acceptance date:
2021-12-23
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
34957475
Language:
English
Keywords:
Pubs id:
1226871
Local pid:
pubs:1226871
Deposit date:
2022-03-28

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP