Journal article
Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice
- Abstract:
-
Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP participants and n = 86 healthy controls) and facial EMG (n = 3 CIP participants and n = 8 healthy controls) we have found that these patients also have abnormalities in the encoding of affective touch which is mediated by the specialised afferents; C-low th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Brain Journal website
- Volume:
- 145
- Issue:
- 10
- Pages:
- 3637–3653
- Place of publication:
- England
- Publication date:
- 2021-12-27
- Acceptance date:
- 2021-12-23
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Pmid:
-
34957475
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1226871
- Local pid:
- pubs:1226871
- Deposit date:
- 2022-03-28
Terms of use
- Copyright holder:
- Middleton et al
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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