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Adjuvant treatment for POLE proofreading domain-mutant cancers: sensitivity to radiotherapy, chemotherapy, and nucleoside analogues

Abstract:

Purpose: Pathogenic POLE proofreading domain mutations are found in many malignancies where they are associated with ultramutation and favorable prognosis. The extent to which this prognosis depends on their sensitivity to adjuvant treatment is unknown, as is the optimal therapy for advanced-staged or recurrent POLE-mutant cancers. Experimental design: We examined the recurrence-free survival of women with POLE-mutant and POLE-wild-type endometrial cancers (ECs) in the observation arm of the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1078-0432.CCR-18-0266

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Church, D
Grant:
Clinician Scientist Fellowship
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Funding agency for:
Church, D
Grant:
Clinician Scientist Fellowship
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Grant:
Oxford Biomedical Research Centre
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Grant:
KWF-UL2012-5719:ICvG,EMO,RAN,CLC, VTHMBS,TB;
KWF-YoungInvestigatorGrant–10418:TB
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
24
Issue:
13
Pages:
3197-3203
Publication date:
2018-03-20
Acceptance date:
2018-02-26
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Source identifiers:
826894
Keywords:
Pubs id:
pubs:826894
UUID:
uuid:aa14f5f6-4eaf-4b77-9518-592137d6fe0b
Local pid:
pubs:826894
Deposit date:
2018-03-12

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