Journal article icon

Journal article

Fixation and spread of somatic mutations in adult human colonic epithelium

Abstract:

We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately seven active stem cells residing within each colonic crypt has to be mutated. Second, the mutated stem cell has to replace neighbors to populate the entire crypt in a process that takes several years. Subsequent clonal expansion due to crypt fission is infrequent for ne...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.stem.2018.04.020

Authors


Expand authors...
Norwich Research Park BioRepository More from this funder
Norfolk and Norwich University Hospitals NHS Foundation Trust More from this funder
University of East Anglia More from this funder
Addenbrooke’s Human Research Tissue Bank More from this funder
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
Cell Stem Cell Journal website
Volume:
22
Issue:
6
Pages:
909-918
Publication date:
2018-05-17
Acceptance date:
2018-04-23
DOI:
EISSN:
1875-9777
ISSN:
1934-5909
Pubs id:
pubs:853369
URN:
uri:aa0c8363-47c0-4fd2-ab05-8052792f365f
UUID:
uuid:aa0c8363-47c0-4fd2-ab05-8052792f365f
Local pid:
pubs:853369

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP