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Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Abstract:

Female children and adults typically generate more efficacious immune responses to vaccines and infections than age-matched males, but also suffer greater immunopathology and autoimmune disease. We here describe, in a cohort of > 170 in utero HIV-infected infants from KwaZulu-Natal, South Africa, fetal immune sex differences resulting in a 1.5–2-fold increased female susceptibility to intrauterine HIV infection. Viruses transmitted to females have lower replicative capacity (p = 0.0005) and a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-15632-y

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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Issue:
1
Article number:
1767
Publication date:
2020-04-14
Acceptance date:
2020-03-16
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
32286302
Language:
English
Pubs id:
1100527
Local pid:
pubs:1100527
Deposit date:
2020-06-12

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