Journal article
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
- Abstract:
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The orphan receptor small heterodimer partner (SHP, NR0B2) modulates the transcription activity of the MODY1 gene HNF4a. Mutations in SHP were found in 7% of Japanese obese young-onset type 2 diabetic patients and were associated with moderate obesity and increased birth weight. We investigated SHP in 1927 U.K. subjects, examining relationships with type 2 diabetes, obesity, and birth weight. Sequencing of the coding region of SHP in 122 obese, young-onset type 2 diabetic patients detected th...
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- Publication status:
- Published
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- Publisher copy:
- 10.2337/diabetes.52.5.1276
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Authors
Bibliographic Details
- Journal:
- Diabetes
- Volume:
- 52
- Issue:
- 5
- Pages:
- 1276-1279
- Publication date:
- 2003-05-01
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- Source identifiers:
-
9965
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:9965
- UUID:
-
uuid:a904813f-636e-4cd8-89b6-7ab14f6bcb3a
- Local pid:
- pubs:9965
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2003
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