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Atomic force microscopy-indentation demonstrates that alginate beads are mechanically stable under cell culture conditions

Abstract:

Alginate microbeads are extensively used in tissue engineering as microcarriers and cell encapsulation vessels. In this study, we used atomic force microscopy (AFM) based indentation using 20 µm colloidal probes to assess the local reduced elastic modulus (E * ) using a novel method to detect the contact point based on the principle of virtual work, to measure microbead mechanical stability under cell culture conditions for 2 weeks. The bead diameter and swelling were assessed in parallel. Al...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jmbbm.2019.01.019

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-7071-459X
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Institution:
University of Oxford
Department:
Physics
Role:
Author
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Institution:
University of Oxford
Department:
Physics
Role:
Author
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Institution:
University of Oxford
Department:
Physics
Oxford college:
Green Templeton College
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Engineering Science
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0001-7613-6041
Publisher:
Elsevier Publisher's website
Journal:
Journal of the Mechanical Behavior of Biomedical Materials Journal website
Volume:
93
Pages:
61-69
Publication date:
2019-01-30
Acceptance date:
2019-01-22
DOI:
EISSN:
1878-0180
ISSN:
1751-6161
Pubs id:
pubs:967168
UUID:
uuid:a864892d-9638-4605-88d9-f33d2f4e08d5
Source identifiers:
967168
Local pid:
pubs:967168

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