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Journal article

RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

Abstract:

During replication‐coupled DNA interstrand crosslink (ICL) repair, the XPF‐ERCC1 endonuclease is required for the incisions that release, or “unhook”, ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strikes the ICL. Here, we report that while purified XPF‐ERCC1 incises simple ICL‐containing model replication fork structures, the presence of a nascent leading strand, modelling the effects of replica...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embj.201796664

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
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More from this funder
Funding agency for:
McHugh, P
Grant:
MR/L007665/1
More from this funder
Funding agency for:
El-Sagheer, A
Grant:
BB/J001694/1
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
36
Issue:
14
Pages:
2047-2060
Publication date:
2017-06-12
Acceptance date:
2017-05-24
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
697028
Pubs id:
pubs:697028
UUID:
uuid:a76471fe-9f2b-4d21-8a1e-0961a19b8d99
Local pid:
pubs:697028
Deposit date:
2017-05-24

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