Journal article
RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
- Abstract:
-
During replication‐coupled DNA interstrand crosslink (ICL) repair, the XPF‐ERCC1 endonuclease is required for the incisions that release, or “unhook”, ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strikes the ICL. Here, we report that while purified XPF‐ERCC1 incises simple ICL‐containing model replication fork structures, the presence of a nascent leading strand, modelling the effects of replica...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Brown, T
El-Sagheer, A
Grant:
BB/J001694/1
BB/J001694/1
+ King Abdullah University of Science and Technology
More from this funder
Funding agency for:
McGouran, J
Bibliographic Details
- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 36
- Issue:
- 14
- Pages:
- 2047-2060
- Publication date:
- 2017-06-12
- Acceptance date:
- 2017-05-24
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
Item Description
- Pubs id:
-
pubs:697028
- UUID:
-
uuid:a76471fe-9f2b-4d21-8a1e-0961a19b8d99
- Local pid:
- pubs:697028
- Source identifiers:
-
697028
- Deposit date:
- 2017-05-24
Terms of use
- Copyright holder:
- Abdullah et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published under the terms of the CC BY 4.0 license.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record