Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Pharmacological targeting of transcription factors (TF) holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have yielded limited success. TFs typically engage in complex interaction networks, likely masking the effects of specifically inhibiting single protein-protein interactions. Here, we used a combination of genomic, proteomic and biophysical methods to discover a suite o...Expand abstract
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- Overman et al
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Copyright © 2017 Overman et al.
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