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Journal article

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Abstract:

Pharmacological targeting of transcription factors (TF) holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have yielded limited success. TFs typically engage in complex interaction networks, likely masking the effects of specifically inhibiting single protein-protein interactions. Here, we used a combination of genomic, proteomic and biophysical methods to discover a suite o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.21221

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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Article number:
e21221
Publication date:
2017-01-01
Acceptance date:
2016-12-07
DOI:
ISSN:
2050-084X
Source identifiers:
666082
Keywords:
Pubs id:
pubs:666082
UUID:
uuid:a6b10b1a-0443-4a8b-b926-8632e59228c5
Local pid:
pubs:666082
Deposit date:
2016-12-15

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