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Engineering of single magnetic particle carrier for living brain cell imaging: A tunable T1-/T2-/dual-modal contrast agent for magnetic resonance imaging application

Abstract:

Despite a variety of T1-T2 dual-modal contrast agents (DMCAs) reported for magnetic resonance imaging (MRI), no tuning of local induced magnetic field strength of an DMCA, which is important to modulate the overall T1 and T2 responses for imaging delicate cells, tissues, and organs, is yet available. Here, we show that a spatial arrangement of T1 and T2 components within a "nano zone" in a single core-shell nanoparticle carrier (i.e., DMCA with core Fe3O4 and MnO clusters in a silica shell) t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.chemmater.7b00884

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Inorganic Chemistry
Role:
Author
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Hong Kong Polytechnic University More from this funder
Ministry of Science and Technology of Taiwan More from this funder
University of Oxford More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Chemistry of Materials Journal website
Volume:
29
Issue:
10
Pages:
4411-4417
Publication date:
2017-05-01
Acceptance date:
2017-05-02
DOI:
EISSN:
1520-5002
ISSN:
0897-4756
Source identifiers:
698749
Keywords:
Pubs id:
pubs:698749
UUID:
uuid:a68828bb-0895-4c25-8896-8e52bc53ee71
Local pid:
pubs:698749
Deposit date:
2017-10-19

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