Journal article
Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
- Abstract:
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The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the "up" and "down" conformations. However, recent studies have resulted in contradictory and mutually exclusive conclusions about the functional (i.e., conductive) status of these two conformations. To address this problem, we have used the state-dependent TREK-2 inhibitor norfluo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.6MB)
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- Publisher copy:
- 10.1085/jgp.201611601
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Authors
Funding
Wellcome Trust
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German Research Foundation
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Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of General Physiology Journal website
- Volume:
- 147
- Issue:
- 6
- Pages:
- 497-505
- Publication date:
- 2016-05-01
- Acceptance date:
- 2016-05-09
- DOI:
- EISSN:
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1540-7748
- ISSN:
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0022-1295
- Pmid:
-
27241700
- Source identifiers:
-
625393
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:625393
- UUID:
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uuid:a609ef5a-ea28-4658-a668-e396b0836ab0
- Local pid:
- pubs:625393
- Deposit date:
- 2018-03-26
Terms of use
- Copyright holder:
- McClenaghan et al
- Copyright date:
- 2016
- Notes:
- © 2016 McClenaghan et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
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