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Journal article

Deficiency of filaggrin regulates endogenous cysteine protease activity, leading to impaired skin barrier function

Abstract:

BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disorder, characterized by skin barrier defects and enhanced allergen priming. Null mutations in the filaggrin gene (FLG) are strongly associated with moderate to severe AD, but the pathways linking barrier dysfunction and cutaneous inflammation are still largely unknown.

AIM: To assess alteration of endogenous cysteine protease activity in FLG-deficient keratinocytes, and to determine whether the alteration in cystein...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/ced.13113

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Institution:
University of Oxford
Oxford college:
Somerville College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
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Medical Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
Wiley Publisher's website
Journal:
Clinical and Experimental Dermatology Journal website
Volume:
42
Issue:
6
Pages:
622-631
Publication date:
2017-05-29
Acceptance date:
2016-10-07
DOI:
EISSN:
1365-2230
ISSN:
0307-6938
Source identifiers:
697944
Language:
English
Keywords:
Pubs id:
pubs:697944
UUID:
uuid:a5a83aca-ad7d-45bb-9738-71d49e3ef366
Local pid:
pubs:697944
Deposit date:
2017-06-14

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