Journal article
Deficiency of filaggrin regulates endogenous cysteine protease activity, leading to impaired skin barrier function
- Abstract:
-
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disorder, characterized by skin barrier defects and enhanced allergen priming. Null mutations in the filaggrin gene (FLG) are strongly associated with moderate to severe AD, but the pathways linking barrier dysfunction and cutaneous inflammation are still largely unknown.
AIM: To assess alteration of endogenous cysteine protease activity in FLG-deficient keratinocytes, and to determine whether the alteration in cystein...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Medical Research Council
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National Institute for Health Research
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Clinical and Experimental Dermatology Journal website
- Volume:
- 42
- Issue:
- 6
- Pages:
- 622-631
- Publication date:
- 2017-05-29
- Acceptance date:
- 2016-10-07
- DOI:
- EISSN:
-
1365-2230
- ISSN:
-
0307-6938
- Source identifiers:
-
697944
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:697944
- UUID:
-
uuid:a5a83aca-ad7d-45bb-9738-71d49e3ef366
- Local pid:
- pubs:697944
- Deposit date:
- 2017-06-14
Terms of use
- Copyright holder:
- © 2017 British Association of Dermatologists
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Wiley at: 10.1111/ced.13113
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