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Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials

Abstract:

AIMS/HYPOTHESIS: Observational studies suggest that metformin may reduce cancer risk by approximately one-third. We examined cancer outcomes and all-cause mortality in published randomised controlled trials (RCTs). METHODS: RCTs comparing metformin with active glucose-lowering therapy or placebo/usual care, with minimum 500 participants and 1-year follow-up, were identified by systematic review. Data on cancer incidence and all-cause mortality were obtained from publications or by contacting ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00125-012-2653-7

Authors


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Institution:
University of Oxford
Division:
Societies, Other & Subsidiary Companies
Department:
Kellogg College
Oxford college:
Kellogg College
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Green Templeton College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Societies, Other & Subsidiary Companies
Department:
Kellogg College
Oxford college:
Kellogg College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Publisher:
Springer Publisher's website
Journal:
Diabetologia Journal website
Volume:
55
Issue:
10
Pages:
2593-2603
Publication date:
2012-08-10
Acceptance date:
2012-06-12
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Pmid:
22875195
Source identifiers:
345596
Language:
English
Keywords:
Pubs id:
pubs:345596
UUID:
uuid:a57ac6c6-dea6-482c-9eff-99ec6d612f6e
Local pid:
pubs:345596
Deposit date:
2016-12-14

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