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Journal article

Polygenic risk scores for prediction of breast cancer and breast cancer subtypes

Abstract:

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ajhg.2018.11.002

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Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
104
Issue:
1
Pages:
21-34
Publication date:
2018-12-13
Acceptance date:
2018-11-03
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pmid:
30554720
Source identifiers:
953162
Language:
English
Keywords:
Pubs id:
pubs:953162
UUID:
uuid:a509cd34-0957-4e56-934a-59188a0bfd4b
Local pid:
pubs:953162
Deposit date:
2019-04-05

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